Phenotyping multiple subsets in Sjogren's syndrome: a salivary proteomic SWATH-MS approach towards precision medicine.

ABSTRACT:

Background

This proof of concept study was aimed at characterizing novel salivary biomarkers specific for different subsets in primary Sjögren's syndrome (pSS) in order to improve patients' profiling.

Methods

pSS patients were stratified in three subgroups according to both (a) focus score in the minor salivary gland biopsies (i.e. intensity of immune cell infiltration in the tissue) and (b) unstimulated salivary flow rate. Healthy volunteers were included as controls. A nano-HPLC-SWATH-MS approach was used for the analysis of saliva proteome of different subsets.

Results

We found 203 differentially expressed proteins in pSS patients with respect to controls with evident differences in the expression of normal constituents of the human salivary proteome (i.e. prolacti

SUBMITTER: Cecchettini A 

PROVIDER: S-EPMC6587286 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature