Synchronous profiling and analysis of mRNAs and ncRNAs in the dermal papilla cells from cashmere goats.

ABSTRACT:

Background

Dermal papilla cells (DPCs), the "signaling center" of hair follicle (HF), delicately master continual growth of hair in mammals including cashmere, the fine fiber annually produced by secondary HF embedded in cashmere goat skins. Such unparalleled capacity bases on their exquisite character in instructing the cellular activity of hair-forming keratinocytes via secreting numerous molecular signals. Past studies suggested microRNA (miRNAs) and long non-coding RNAs (lncRNAs) play essential roles in a wide variety of biological process, including HF cycling. However, their roles and related molecular mechanisms in modulating DPCs secretory activities are still poorly understood.

Results

Here, we separately cultivated DPCs and their functionally and morphologically di

SUBMITTER: Ma S 

PROVIDER: S-EPMC6587304 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature