Metoclopramide as a prokinetic agent for diabetic gastroparesis: revisiting the risk of Parkinsonism.

ABSTRACT:

Background

Metoclopramide is used to relieve gastrointestinal symptoms, however, it could cause adverse reactions of motor disorders. The aim of this study was to investigate whether metoclopramide treatment has a duration-response or dose-response effect and to estimate the risk of developing Parkinsonism following different and specific durations of treatment.

Methods

A cohort study of newly diagnosed type 2 diabetes mellitus in 45- to 79-year-old patients, between 1999 and 2008, was selected using the Longitudinal Health Insurance Database 2005. A nested case-control study was conducted in the diabetes cohort in which all incident cases of Parkinsonism were identified. We randomly matched each case with up to 10 controls from the risk set. Conditional logistic regression

SUBMITTER: Lai CH 

PROVIDER: S-EPMC6587390 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature