Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury.

ABSTRACT: Oxandrolone, a testosterone analog, is used to counteract the catabolic effects of burn injury. Recent animal studies suggest a possible hormonal association with heterotopic ossification (HO) development postburn. This work examines oxandrolone administration and HO development by exploring historical clinical data bridging the introduction of oxandrolone into clinical practice. Additionally, we examine associations between oxandrolone administration and HO in a standardized mouse model of burn/trauma-related HO. Acutely burned adults admitted between 2000 and 2014, survived through discharge, and had a HO risk factor of 7 or higher were selected for analysis from a single burn center. Oxandrolone administration, clinical and demographic data, and elbow HO were recorded and were analyzed

SUBMITTER: Thorpe CR 

PROVIDER: S-EPMC6587410 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature