Prevalence of drug resistance mutations among ART-naive and -experienced HIV-infected patients in Sierra Leone.

ABSTRACT:

Objectives

The aim of this study was to assess the prevalence of HIV drug resistance (HIVDR) in HIV-infected ART-naive and -experienced patients in Sierra Leone.

Patients and methods

We conducted a cross-sectional study of HIV-positive adults aged ≥18 years at Connaught Hospital in Freetown, Sierra Leone in November 2017. Sequencing was performed in the reverse transcriptase, protease and integrase regions, and interpreted using the Stanford HIVDR database and WHO 2009 mutation list.

Results

Two hundred and fifteen HIV-infected patients were included (64 ART naive and 151 ART experienced). The majority (66%) were female, the median age was 36 years and the median ART exposure was 48 months. The majority (83%) were infected with HIV-1 subtype CRF02_AG. In the ART-naive

SUBMITTER: Yendewa GA 

PROVIDER: S-EPMC6587425 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature