Circulating miRNAs in localized/locally advanced prostate cancer patients after radical prostatectomy and radiotherapy.

ABSTRACT:

Background

Overtreatment is a well-known clinical challenge in local prostate cancer (PCa). Although risk assessment models have contributed to a better stratification of patients with local PCa, a tailored management is still in its infancy. Over the last few decades, microRNAs (miRNAs) have shown promising results as biomarkers in PCa. The aim of this study was to investigate circulating miRNAs after management of local PCa.

Methods

The relative expression of four miRNAs (miRNA-21, -93, -125b, and miRNA-221) was assessed in plasma from 149 newly diagnosed patients with local or locally advanced PCa. Real-time polymerase chain reaction was used for analysis. A baseline sample at time of diagnosis and a follow-up sample after 6 months were assessed. The patients were grouped

SUBMITTER: Zedan AH 

PROVIDER: S-EPMC6587522 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature