Active vaccination against interleukin-5 as long-term treatment for insect-bite hypersensitivity in horses.

ABSTRACT:

Background

Insect-bite hypersensitivity (IBH) in horses is a chronic allergic dermatitis caused by insect bites. Horses suffer from pruritic skin lesions, caused by type-I/type-IV allergic reactions accompanied by prominent eosinophil infiltration into the skin. Interleukin-5 (IL-5) is the key cytokine for eosinophils and we have previously shown that targeting IL-5 by vaccination reduces disease symptoms in horses.

Objective

Here, we analyzed the potential for long-term therapy by assessing a second follow-up year of the previously published study.

Methods

The vaccine consisted of equine IL-5 (eIL-5) covalently linked to a cucumber mosaic virus-like particle (VLP) containing a universal T cell epitope (CuMV_TT ) using a semi-crossover design to follow vacci

SUBMITTER: Fettelschoss-Gabriel A 

PROVIDER: S-EPMC6587569 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature