Ontology highlight
ABSTRACT:
SUBMITTER: Hochberg GKA
PROVIDER: S-EPMC6587588 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180201 6378
Oligomeric proteins assemble with exceptional selectivity, even in the presence of closely related proteins, to perform their cellular roles. We show that most proteins related by gene duplication of an oligomeric ancestor have evolved to avoid hetero-oligomerization and that this correlates with their acquisition of distinct functions. We report how coassembly is avoided by two oligomeric small heat-shock protein paralogs. A hierarchy of assembly, involving intermediates that are populated only ...[more]