Compartmentalized gut lymph node drainage dictates adaptive immune responses.

ABSTRACT: The intestinal immune system has the challenging task of tolerating foreign nutrients and the commensal microbiome, while excluding or eliminating ingested pathogens. Failure of this balance leads to conditions such as inflammatory bowel diseases, food allergies and invasive gastrointestinal infections¹. Multiple immune mechanisms are therefore in place to maintain tissue integrity, including balanced generation of effector T (T_H) cells and FOXP3⁺ regulatory T (pT_reg) cells, which mediate resistance to pathogens and regulate excessive immune activation, respectively^1-4. The gut-draining lymph nodes (gLNs) are key sites for orchestrating adaptive immunity to luminal perturbations^5-7. However, it is unclear how they simultaneo

SUBMITTER: Esterhazy D 

PROVIDER: S-EPMC6587593 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature