Severity, course trajectory, and within-person variability of individual symptoms in patients with major depressive disorder.

ABSTRACT:

Background

Depression shows a large heterogeneity of symptoms between and within persons over time. However, most outcome studies have assessed depression as a single underlying latent construct, using the sum score on psychometric scales as an indicator for severity. This study assesses longitudinal symptom-specific trajectories and within-person variability of major depressive disorder over a 9-year period.

Methods

Data were derived from the Netherlands Study of Depression and Anxiety (NESDA). This study included 783 participants with a current major depressive disorder at baseline. The Inventory Depressive Symptomatology-Self-Report (IDS-SR) was used to analyze 28 depressive symptoms at up to six time points during the 9-year follow-up.

Results

The highest baseline

SUBMITTER: van Eeden WA 

PROVIDER: S-EPMC6587785 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature