Second-generation antipsychotic long-acting injections in bipolar disorder: Systematic review and meta-analysis.

ABSTRACT:

Background

Non-adherence is a significant problem in bipolar disorder. Second-generation antipsychotics (SGA) long-acting injections (LAIs) may improve adherence in bipolar disorder and may prevent relapses. However, the evidence is limited and conflicting.

Objective

The objective of this study was to evaluate efficacy and safety of SGA LAIs in bipolar disorder.

Method

Systematic review and meta-analysis of randomised controlled trials (RCTs) (≥6 months duration) investigating safety and efficacy of SGA LAIs for bipolar disorder. We searched Pubmed, Embase, CINAHL, Cochrane, PsycINFO, LiLACS, www.clinicaltrials.gov up to October 2016. We also contacted the manufacturers of SGA LAIs. Primary efficacy and safety outcomes were relapse rate and all-cause discontinuation r

SUBMITTER: Prajapati AR 

PROVIDER: S-EPMC6587954 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature