Differences in biocompatibility of microneedles from cyclic olefin polymers with human endothelial and epithelial skin cells.

ABSTRACT: Microneedles are promising devices for transdermal delivery and diagnostic applications, due to their minimally invasive and painless nature of application. However, so far, applications are limited to small scale research projects. Material selection and production for larger projects remain a challenge. In vitro testing using human cell culture could bridge the gap between cost effective screening of suitable materials and concerns for safety and ethics. In this study, materials were tested for effects on viability and morphology of human endothelial cells and keratinocytes. In addition, materials were assessed for their potential to influence cellular differentiation and barrier formation. Elution-based testing of inflammatory markers revealed no negative effects in all applied tests, w

SUBMITTER: Schossleitner K 

PROVIDER: S-EPMC6587957 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature