Blood draws up to 3% of blood volume in clinical trials are safe in children.

ABSTRACT:

Aim

Recommendations for maximum blood draw in children range from 1 to 5% despite limited evidence. The aim of the study was to assess the safety of blood draws in children aged six months to 12 years targeting volumes of 3% of total blood volume.

Methods

Children who experienced three-monthly blood draws during participation in one of three investigators initiated clinical trials conducted in our institution were examined. In total, 629 venous blood draws were performed in 141 children. Adverse events and blood counts were assessed.

Results

Overall, 608 adverse events were reported. None of these included symptoms that reflected concerns on blood draw volumes or frequency. Anaemia and red cell or haemoglobin measurements outside the normal age range were not observed

SUBMITTER: Peplow C 

PROVIDER: S-EPMC6587985 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature