Efficacy and Safety of Transnasal CoolStat Cooling Device to Induce and Maintain Hypothermia.

ABSTRACT: Targeted temperature management (TTM) is recommended as a standard of care for postcardiac arrest patients. Current TTM methods have significant limitations to be used in an ambulatory setting. We investigated the efficacy and safety of a novel noninvasive transnasal evaporative cooling device (CoolStat™). Eleven Yorkshire pigs underwent hypothermia therapy using the CoolStat device. CoolStat induces evaporative cooling by blowing dehumidified ambient air over the nasal turbinates in a unidirectional fashion. CoolStat's efficacy and safety were assessed by applying different cooling strategies (groups A, B and C). In group A (efficacy study; n = 5, TTM for 8 hours), time to achieve brain target temperature (2°C reduction from baseline), and the percentage of time in which the temper

SUBMITTER: Assis FR 

PROVIDER: S-EPMC6588101 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature