Prominent Non-Memory Deficits in Alzheimer's Disease Are Associated with Faster Disease Progression.

ABSTRACT:

Background

Alzheimer's disease (AD) is a heterogeneous disorder.

Objective

To investigate whether cognitive AD subtypes are associated with different rates of disease progression.

Methods

We included 1,066 probable AD patients from the Amsterdam Dementia Cohort (n = 290), Alzheimer's Disease Neuroimaging Initiative (n = 268), Dementia Competence Network (n = 226), and University of California, San Francisco (n = 282) with available follow-up data. Patients were previously clustered into two subtypes based on their neuropsychological test results: one with most prominent memory impairment (n = 663) and one with most prominent non-memory impairment (n = 403). We examined associations between cognitive subtype and disease progression, as measured with repeated Mini-Menta

SUBMITTER: Scheltens NME 

PROVIDER: S-EPMC6588161 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature