Familial Clustering of Cardiac Conduction Defects and Pacemaker Insertion.

ABSTRACT:

Background

The etiopathogenesis of electrocardiographic bundle branch and atrioventricular blocks is not fully understood. We investigated familial clustering of cardiac conduction defects and pacemaker insertion in the FHS (Framingham Heart Study). Additionally, we assessed familial clustering of pacemaker insertion in the Danish general population.

Methods

In FHS, we used multivariable-adjusted logistic regression models to investigate the association of parental atrioventricular block (PR interval, ≥0.2 s), complete bundle branch block (QRS, ≥0.12 s), or pacemaker insertion with the occurrence of cardiac conduction abnormalities in their offspring. The Danish nationwide administrative registries were interrogated to assess the relations of parental pacemaker insertion wit

SUBMITTER: Kaess BM 

PROVIDER: S-EPMC6588168 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature