Paradoxical relationship between body mass index and bone mineral density in patients with non-small cell lung cancer with brain metastasis.

ABSTRACT:

Background and purpose

Low body mass index (BMI) at presentation has been reported to be associated with higher incidence and mortality of lung cancer, but studies on the relationship between brain metastasis and BMI at presentation are lacking. This study aimed to evaluate the association between brain metastasis and BMI and bone mineral density (BMD) in NSCLC.

Methods

We retrospectively enrolled patients with non-small cell lung cancer who underwent brain magnetic resonance imaging with contrast within 3 months of diagnosis. The BMI was collected, and the BMD was measured in Hounsfield unit (HU) on initial staging computed tomography scans. The independent relationship between BMI and BMD was assessed using multivariable linear regression according to the presence of brain

SUBMITTER: Nam MW 

PROVIDER: S-EPMC6588256 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature