Metabolic reprogramming dynamics in tumor spheroids: Insights from a multicellular, multiscale model.

ABSTRACT: Mathematical modeling provides the predictive ability to understand the metabolic reprogramming and complex pathways that mediate cancer cells' proliferation. We present a mathematical model using a multiscale, multicellular approach to simulate avascular tumor growth, applied to pancreatic cancer. The model spans three distinct spatial and temporal scales. At the extracellular level, reaction diffusion equations describe nutrient concentrations over a span of seconds. At the cellular level, a lattice-based energy driven stochastic approach describes cellular phenomena including adhesion, proliferation, viability and cell state transitions, occurring on the timescale of hours. At the sub-cellular level, we incorporate a detailed kinetic model of intracellular metabolite dynamics on the tim

SUBMITTER: Roy M 

PROVIDER: S-EPMC6588258 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature