Thiol-Ene Alginate Hydrogels as Versatile Bioinks for Bioprinting.

ABSTRACT: Bioprinting is a powerful technique that allows precise and controlled 3D deposition of biomaterials in a predesigned, customizable, and reproducible manner. Cell-laden hydrogel ("bioink") bioprinting is especially advantageous for tissue engineering applications as multiple cells and biomaterial compositions can be selectively dispensed to create spatially well-defined architectures. Despite this promise, few hydrogel systems are easily available and suitable as bioinks, with even fewer systems allowing for molecular design of mechanical and biological properties. In this study, we report the development of a norbornene functionalized alginate system as a cell-laden bioink for extrusion-based bioprinting, with a rapid UV-induced thiol-ene cross-linking mechanism that avoids acrylate kinet

SUBMITTER: Ooi HW 

PROVIDER: S-EPMC6588269 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature