Effect of Testosterone on Natriuretic Peptide Levels.

ABSTRACT:

Background

Circulating natriuretic peptide (NP) levels are markedly lower in healthy men than women. A relative NP deficiency in men could contribute to their higher risk of hypertension and cardiovascular disease. Epidemiological studies suggest testosterone may contribute to sex-specific NP differences.

Objectives

This study aimed to determine the effect of testosterone administration on NP levels using a randomized, placebo-controlled design.

Methods

One hundred and fifty-one healthy men (20 to 50 years of age) received goserelin acetate to suppress endogenous production of gonadal steroids, and anastrazole to suppress conversion of testosterone to estradiol. Subjects were randomized to placebo gel or 4 different doses of testosterone (1%) gel for 12 weeks. Serum N

SUBMITTER: Bachmann KN 

PROVIDER: S-EPMC6588352 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature