Prognostic Implications of Mucinous Differentiation in Metastatic Colorectal Carcinoma Can Be Explained by Distinct Molecular and Clinicopathologic Characteristics.

ABSTRACT:

Background

The mucinous histologic subtype accounts for 5% to 20% of colorectal cancer (CRC) cases but remains poorly characterized. The present study characterized the baseline characteristics, mutational profile, and clinical outcomes of patients diagnosed with mucinous CRC.

Materials and methods

We identified 1877 patients with metastatic CRC with available histologic findings and molecular profiling and summarized the baseline clinical and pathologic characteristics and overall survival (OS) stratified by the histologic type. The data from separate cohorts with consensus molecular subtype (CMS) and CpG island methylator information were also summarized.

Results

The mucinous histologic type was found in 277 of the 1877 patients (14.8%) and was associated with an in

SUBMITTER: Khan M 

PROVIDER: S-EPMC6588353 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature