Intra-tumor molecular heterogeneity in breast cancer: definitions of measures and association with distant recurrence-free survival.

ABSTRACT:

Purpose

The purpose of the study was to define quantitative measures of intra-tumor heterogeneity in breast cancer based on histopathology data gathered from multiple samples on individual patients and determine their association with distant recurrence-free survival (DRFS).

Methods

We collected data from 971 invasive breast cancers, from 1st January 2000 to 23rd March 2014, that underwent repeat tumor sampling at our institution. We defined and calculated 31 measures of intra-tumor heterogeneity including ER, PR, and HER2 immunohistochemistry (IHC), proliferation, EGFR IHC, grade, and histology. For each heterogeneity measure, Cox proportional hazards models were used to determine whether patients with heterogeneous disease had different distant recurrence-free survival (DR

SUBMITTER: Saha A 

PROVIDER: S-EPMC6588400 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature