Resistance to leukocytes ties benefits of quorum sensing dysfunctionality to biofilm infection.

ABSTRACT: Social interactions play an increasingly recognized key role in bacterial physiology¹. One of the best studied is quorum sensing (QS), a mechanism by which bacteria sense and respond to the status of cell density². While QS is generally deemed crucial for bacterial survival, QS-dysfunctional mutants frequently arise in in vitro culture. This has been explained by the fitness cost an individual mutant, a 'quorum cheater', saves at the expense of the community³. QS mutants are also often isolated from biofilm-associated infections, including cystic fibrosis lung infection⁴, as well as medical device infection and associated bacteraemia^5-7. However, despite the frequently proposed use of QS blockers to control virulence⁸, the m

SUBMITTER: He L 

PROVIDER: S-EPMC6588452 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature