Curative-intent radiotherapy for pediatric osteosarcoma: The St. Jude experience.

ABSTRACT:

Background

Radiation therapy (RT) confers local tumor control and survival advantages in some patients with osteosarcoma, yet pediatric and adolescent and young adult (AYA) population studies are limited.

Methods

Twenty-eight patients treated with curative-intent RT (median dose, 59.4 Gy; range, 40-76 Gy) at our institution from 1990 to 2017 were retrospectively identified. Cumulative incidence (CIN) of local failure (LF) was estimated by Gray's method and overall survival (OS) by the Kaplan-Meier method. Competing-risk regression and Cox proportional hazards models determined predictors of outcome. Toxicity was reported according to CTCAE v4.0.

Results

With a median follow-up of 99.1 months in living patients, nine patients (32.1%) developed LF. Estimated CINs of LF

SUBMITTER: Tinkle CL 

PROVIDER: S-EPMC6588458 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature