Doxycycline Reduces Scar Thickness and Improves Collagen Architecture.

ABSTRACT:

Objective

To investigate the effects of local doxycycline administration on skin scarring.

Background

Skin scarring represents a major source of morbidity for surgical patients. Doxycycline, a tetracycline antibiotic with off-target effects on the extracellular matrix, has demonstrated antifibrotic effects in multiple organs. However, doxycycline's potential effects on skin scarring have not been explored in vivo.

Methods

Female C57BL/6J mice underwent dorsal wounding following an established splinted excisional skin wounding model. Doxycycline was administered by local injection into the wound base following injury. Wounds were harvested upon complete wound closure (postoperative day 15) for histological examination and biomechanical testing of scar tissue.

Result

SUBMITTER: Moore AL 

PROVIDER: S-EPMC6588503 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature