Histone Deacetylase Inhibitors: A Novel Strategy in Trauma and Sepsis.

ABSTRACT: Trauma remains a leading cause of morbidity and mortality among all age groups in the United States. Hemorrhagic shock and traumatic brain injury (TBI) are major causes of preventable death in trauma. Initial treatment involves fluid resuscitation to improve the intravascular volume. Although crystalloids may provide volume expansion, they do not have any pro-survival properties. Furthermore, aggressive fluid resuscitation can provoke a severe inflammatory response and worsen clinical outcomes. Due to logistical constraints, however, definitive resuscitation with blood products is often not feasible in the prehospital setting-highlighting the importance of adjunctive therapies. In recent years, histone deacetylase inhibitors (HDACis) have shown promise as pharmacologic agents for use in bo

SUBMITTER: Williams AM 

PROVIDER: S-EPMC6588509 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature