Ontology highlight
ABSTRACT:
SUBMITTER: Eissmann MF
PROVIDER: S-EPMC6588585 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Nature communications 20190621 1
The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess the impact of tumor-adjacent, submucosal mast cell accumulation in murine and human intestinal-type gastric cancer. We find that genetic ablation or therapeutic inactivation of mast cells suppresses accumulation of tumor-associated macrophages, reduces tumor cell proliferation and angiogenesis, and diminishes tumor burden. Mast cells are activated by interleukin (IL)-33 ...[more]