Lupin (Lupinus spp.) seeds exert anthelmintic activity associated with their alkaloid content.

ABSTRACT: The growing range of drug resistant parasitic nematode populations threatens the sustainability of ruminant farming worldwide. In this context, nutraceuticals, animal feed that provides necessary dietary requirements while ensuring parasite control, could contribute to increase farming sustainability in developed and low resource settings. In this study, we evaluated the anthelmintic potential of lupin seed extracts against the major ruminant trichostrongylids, Haemonchus contortus and Teladorsagia circumcincta. In vitro observations showed that seed extracts from commercially available lupin varieties could significantly but moderately inhibit larval migration. This anthelmintic effect was mediated by the seed alkaloid content and was potent against both fully susceptible and multidrug re

SUBMITTER: Dubois O 

PROVIDER: S-EPMC6588613 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature