Dataset Information
Chondroprotective Factors in Osteoarthritis: a Joint Affair.
Ontology highlight
ABSTRACT: Purpose of the review
Osteoarthritis is widely regarded as a spectrum of conditions that affect all joint tissues, typified by a common entity: cartilage loss. Here, we review recent progress and challenges in chondroprotection and discuss new strategies to prevent cartilage loss in osteoarthritis.Recent findings
Advances in clinical, molecular, and cellular characterization are enabling improved stratification of osteoarthritis subtypes. Integration of next-generation sequencing and "omics" approaches with clinically relevant readouts shows promise in delineating both subtypes of disease and meaningful trial end points. Novel delivery strategies are enabling joint-specific delivery. Chondroprotection requires a whole joint approach, stratification of patient groups, and use of patient-relevant end points. Drug development should continue to explore new targets, while using modern technologies and recent knowledge to re-visit unsuccessful therapeutics from the past. The overarching goal for chondroprotection is to provide the right treatment(s) for the right patient at the right time.
SUBMITTER: Mimpen JY
PROVIDER: S-EPMC6588640 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Chondroprotective Factors in Osteoarthritis: a Joint Affair.
Current rheumatology reports 20190621 8
<h4>Purpose of the review</h4>Osteoarthritis is widely regarded as a spectrum of conditions that affect all joint tissues, typified by a common entity: cartilage loss. Here, we review recent progress and challenges in chondroprotection and discuss new strategies to prevent cartilage loss in osteoarthritis.<h4>Recent findings</h4>Advances in clinical, molecular, and cellular characterization are enabling improved stratification of osteoarthritis subtypes. Integration of next-generation sequencing ...[more]