Chondroprotective Factors in Osteoarthritis: a Joint Affair.

ABSTRACT:

Purpose of the review

Osteoarthritis is widely regarded as a spectrum of conditions that affect all joint tissues, typified by a common entity: cartilage loss. Here, we review recent progress and challenges in chondroprotection and discuss new strategies to prevent cartilage loss in osteoarthritis.

Recent findings

Advances in clinical, molecular, and cellular characterization are enabling improved stratification of osteoarthritis subtypes. Integration of next-generation sequencing and "omics" approaches with clinically relevant readouts shows promise in delineating both subtypes of disease and meaningful trial end points. Novel delivery strategies are enabling joint-specific delivery. Chondroprotection requires a whole joint approach, stratification of patient groups, and us

SUBMITTER: Mimpen JY 

PROVIDER: S-EPMC6588640 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature