Characterization of functional subgroups among genetically identified cholinergic neurons in the pedunculopontine nucleus.

ABSTRACT: The pedunculopontine nucleus (PPN) is a part of the reticular activating system which is composed of cholinergic, glutamatergic and GABAergic neurons. Early electrophysiological studies characterized and grouped PPN neurons based on certain functional properties (i.e., the presence or absence of the A-current, spike latency, and low threshold spikes). Although other electrophysiological characteristics of these neurons were also described (as high threshold membrane potential oscillations, great differences in spontaneous firing rate and the presence or absence of the M-current), systematic assessment of these properties and correlation of them with morphological markers are still missing. In this work, we conducted electrophysiological experiments on brain slices of genetically identified

SUBMITTER: Baksa B 

PROVIDER: S-EPMC6588655 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature