Mitochondria-Targeted and Resveratrol-Loaded Dual-Function Titanium Disulfide Nanosheets for Photothermal-Triggered Tumor Chemotherapy.

ABSTRACT: A subcellular organelle-targeted delivery of anti-cancer drugs is a promising strategy to maximize the anti-cancer effects and minimize the adverse effects. Herein, we prepared a mitochondria-targeted drug delivery nanoplatform based on IR780 iodide (IR780) and titanium disulfide (TiS₂) nanosheets. Due to the large specific surface area of TiS₂ nanosheets, the nanoplatform could highly load anti-cancer drug resveratrol (RV). The as-prepared nanocomposite (IR780-TiS₂/RV) was used for an efficacious photothermal-triggered tumor chemotherapy. IR780-TiS₂/RV showed satisfactory stability and biocompatibility, and the loading ratio of RV and IR780 was about 112% and 56%, respectively. Upon the near-infrared (NIR) irradiation, the heat generated by IR78

SUBMITTER: Xiang S 

PROVIDER: S-EPMC6588667 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature