Convergent genomic signatures of flight loss in birds suggest a switch of main fuel.

ABSTRACT: Flight loss in birds is as characteristic of the class Aves as flight itself. Although morphological and physiological differences are recognized in flight-degenerate bird species, their contributions to recurrent flight degeneration events across modern birds and underlying genetic mechanisms remain unclear. Here, in an analysis of 295 million nucleotides from 48 bird genomes, we identify two convergent sites causing amino acid changes in ATGL^Ser321Gly and ACOT7^Ala197Val in flight-degenerate birds, which to our knowledge have not previously been implicated in loss of flight. Functional assays suggest that Ser321Gly reduces lipid hydrolytic ability of ATGL, and Ala197Val enhances acyl-CoA hydrolytic activity of ACOT7. Modeling simulations suggest a switch of main ener

SUBMITTER: Pan S 

PROVIDER: S-EPMC6588704 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature