Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide.

ABSTRACT: Protein glycation, also known as nonenzymatic glycosylation, is a spontaneous post-translational modification that would change the structure and stability of proteins or hormone peptides. Recent studies have indicated that glycation plays a role in type 2 diabetes (T2D) and neurodegenerative diseases. Over the last two decades, many types of advanced glycation end products (AGEs), formed through the reactions of an amino group of proteins with reducing sugars, have been identified and detected in vivo. However, the effect of glycation on protein aggregation has not been fully investigated. In this study, we aim to elucidate the impact of protein glycation on islet amyloid polypeptide (IAPP, also known as amylin) aggregation, which was strongly associated with T2D. We chemically synthesize

SUBMITTER: Hsu YH 

PROVIDER: S-EPMC6588732 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature