Chronic inflammatory diseases, anti-inflammatory medications and risk of prostate cancer: a population-based case-control study.

ABSTRACT:

Background

Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with prostate cancer risk.

Methods

Fifty-five thousand nine hundred thirty-seven cases (all prostate cancer, 2007-2012) and 279,618 age-matched controls were selected from the Prostate Cancer Database Sweden. CIDs and AIMs was determined from national patient and drug registers. Associations were investigated using conditional logistic regression, including for disease/drug subtypes and exposure length/dose.

Results

Men with a history of any CID had slightly increased risk of any prostate cancer diagnosis (OR: 1.08; 95%CI: 1.04-1.12) but not 'unfavourable' (

SUBMITTER: Beckmann K 

PROVIDER: S-EPMC6588859 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature