ELL2 Is Downregulated and Associated with Galactose-Deficient IgA1 in IgA Nephropathy.

ABSTRACT:

Background

Galactose-deficient IgA1 (Gd-IgA1) is an important causal factor in IgA nephropathy; however, the underlying mechanism for the production of Gd-IgA1 is unknown. The elongation factor for RNA polymerase II (ELL2), which encoded a key component of the superelongation complex (SEC), drives secretory-specific Ig mRNA production.

Methods

We enrolled 21 patients with IgAN, 18 healthy controls, and 20 patients with non-IgAN glomerulonephritis. The differential expression of ELL2 was compared using publically available data from Gene Expression Omnibus (GEO) datasets. The relationship between ELL2 expressions and galactose-deficient IgA1 (Gd-IgA1) levels in serum were also studied. At last, the results were validated by shELL2 treatment experiment.

Results

We found

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6589307 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature