Impact of Myeloid Reservoirs in HIV Cure Trials.

ABSTRACT: PURPOSE OF REVIEW:Gallant efforts are ongoing to achieve sustained antiretroviral therapy (ART)-free HIV remission in the HIV-infected person; however, most, if not all, current human clinical studies have primarily focused these efforts on targeting viral persistence in CD4 T cells in blood and tissue sanctuaries. The lack of myeloid centered HIV clinical trials, either as primary or secondary end points, has hindered our understanding of the contribution of myeloid cells in unsuccessful trials but may also guide successes in future HIV eradication clinical strategies. RECENT FINDINGS:Recent advances have highlighted the importance of myeloid reservoirs as sanctuaries of HIV persistence and therefore may partially be responsible for viral recrudescence following ART treatment interruption

SUBMITTER: Mitchell BI 

PROVIDER: S-EPMC6589351 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature