Genomic Mismatch at <i>LIMS1</i> Locus and Kidney Allograft Rejection.

ABSTRACT:

Background

In the context of kidney transplantation, genomic incompatibilities between donor and recipient may lead to allosensitization against new antigens. We hypothesized that recessive inheritance of gene-disrupting variants may represent a risk factor for allograft rejection.

Methods

We performed a two-stage genetic association study of kidney allograft rejection. In the first stage, we performed a recessive association screen of 50 common gene-intersecting deletion polymorphisms in a cohort of kidney transplant recipients. In the second stage, we replicated our findings in three independent cohorts of donor-recipient pairs. We defined genomic collision as a specific donor-recipient genotype combination in which a recipient who was homozygous for a gene-intersecting de

SUBMITTER: Steers NJ 

PROVIDER: S-EPMC6589355 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature