Altered functional network topology correlates with clinical measures in very early-stage, drug-naive Parkinson's disease.

ABSTRACT:

Introduction

The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients.

Methods

Functional-MRI data for 16 healthy controls and 20 very early-stage, drug-naïve patients with PD were obtained from the Parkinson's Progression Markers Initiative database after controlling for strict inclusion/exclusion imaging criteria. Connectivity between regions of interest was estimated using Pearson's correlation between averaged time-series, and subsequently a connectivity matrix was obtained for each subject. These connectivity matrices were then used in an unbiased, whole-brain graph theoretical appro

SUBMITTER: Sreenivasan K 

PROVIDER: S-EPMC6589361 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature