Genetic variants in nicotinic receptors and smoking cessation in Parkinson's disease.

ABSTRACT:

Background

Negative associations between smoking and Parkinson's disease (PD) are well documented. While common biases may not explain this association, some studies have suggested reverse causality and ease of quitting might be an early sign of PD, possibly related to a reduced nicotinic response. We investigated nicotinic receptor (nAChR) genetics to add to our understanding of possible biologic mechanisms underlying the smoking-PD relationship.

Methods

We relied on 612 patients and 691 controls enrolled in the PEG (Parkinson's Environment and Gene) study for whom we obtained information on smoking and quitting ease through interviews. Genotyping in the nAChR genes, i.e. CHRNA5-A3-B4 and CHRNB3-A6 gene regions that have been linked to smoking or quitting behaviors, were ba

SUBMITTER: Chuang YH 

PROVIDER: S-EPMC6589367 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature