Genetic variants in acute, acute recurrent and chronic pancreatitis affect the progression of disease in children.

ABSTRACT:

Background/objectives

Acute pancreatitis (AP) is emerging in pediatrics. A subset of children with AP progresses to acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). The role of extensive gene testing in the progression has not been investigated previously. We have followed children enrolled in the registry and at our center for progression to ARP and CP after the first attack.

Methods

This study utilizes an extensive gene sequencing panel as a platform to evaluate the role of genetics in first attack AP, and the progression over time, from first attack to ARP and CP in children.

Results

Genes, with corresponding variants were involved in the 3 groups studied: AP, ARP and CP. We have shown that the presence of gene variants from the eight tested genes

SUBMITTER: Abu-El-Haija M 

PROVIDER: S-EPMC6589390 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature