Chronic pancreatitis changes in high-risk individuals for pancreatic ductal adenocarcinoma.

ABSTRACT:

Background and aims

Pancreatic intraepithelial neoplasia is associated with chronic pancreatitis (CP) changes on EUS. The objective of this study was to determine whether CP changes were more common in high-risk individuals (HRIs) than in control subjects and whether these changes differed among higher-risk subsets of HRIs.

Methods

HRIs and control subjects were identified from an endoscopy database. HRIs were defined as having predisposing mutations or a family history (FH) of pancreatic ductal adenocarcinoma. HRIs were classified as vHRIs who met Cancer of the Pancreas Screening (CAPS) criteria for high risk and mHRIs who did not. Multivariable logistic regression was used to adjust for confounders and CP risk factors.

Results

Sixty-five HRIs (44 vHRIs, 21 mHRIs) an

SUBMITTER: Thiruvengadam SS 

PROVIDER: S-EPMC6589432 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature