Inducible Nitric Oxide Synthase and CD11b⁺Gr1⁺ Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels.

ABSTRACT: Background: Metastatic tumor cells spread through lymphatic vessels and colonize draining lymph nodes (LNs). It is known that tumors induce lymphangiogenesis to enhance lymphatic metastasis and that metastatic cancer cells are carried by lymph flow to LNs. Methods and Results: Here, we investigated the molecular and cellular regulation of collecting lymphatic vessel contraction in vessels draining a metastatic tumor using intravital microscopy. In tumor-draining collecting lymphatic vessels, we found vessel contraction was suppressed. The infiltration of peritumor tissue by inducible nitric oxide synthase positive and CD11b⁺Gr1⁺ myeloid cells played a critical role in the suppression of lymphatic contraction. Depletion of Gr1⁺ ce

SUBMITTER: Liao S 

PROVIDER: S-EPMC6589499 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature