Ontology highlight
ABSTRACT:
SUBMITTER: Paatero I
PROVIDER: S-EPMC6589560 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20181121 2
Tyrosine kinase inhibitors are widely used in the clinic, but limited information is available about their toxicity in developing organisms. Here, we tested the effect of tyrosine kinase inhibitors targeting the ErbB receptors for their effects on developing zebrafish ( Danio rerio) embryos. Embryos treated with wide-spectrum pan-ErbB inhibitors or erbb4a-targeting antisense oligonucleotides demonstrated reduced locomotion, reduced diameter of skeletal muscle fibers, and reduced expression of mu ...[more]