Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review.

ABSTRACT:

Background

Changes in N-linked glycosylation have been observed in the circulation of individuals with hepatocellular carcinoma. In particular, an elevation in the level of core fucosylation has been observed. However, the mechanisms through which core fucose is increased are not well understood. We hypothesized that a review of the literature and related bioinformatic review regarding six genes known to be involved in the attachment of core fucosylation, the synthesis of the fucosylation substrate guanosine diphosphate (GDP)-fucose, or the transport of the substrate into the Golgi might offer mechanistic insight into the regulation of core fucose levels.

Aim

To survey the literature to capture the involvement of genes regulating core N-linked fucosylation in hepatocellular

SUBMITTER: Norton PA 

PROVIDER: S-EPMC6589740 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature