Lymphatic endothelial cell calcium pulses are sensitive to spatial gradients in wall shear stress.

ABSTRACT: Cytosolic calcium (Ca²⁺) is a ubiquitous second messenger that influences numerous aspects of cellular function. In many cell types, cytosolic Ca²⁺ concentrations are characterized by periodic pulses, whose dynamics can influence downstream signal transduction. Here, we examine the general question of how cells use Ca²⁺ pulses to encode input stimuli in the context of the response of lymphatic endothelial cells (LECs) to fluid flow. Previous work shows that fluid flow regulates Ca²⁺ dynamics in LECs and that Ca²⁺-dependent signaling plays a key role in regulating lymphatic valve formation during embryonic development. However, how fluid flow might influence the Ca²⁺ pulse dynamics of individual LECs has remained, to our know

SUBMITTER: Surya VN 

PROVIDER: S-EPMC6589782 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature