Metabolomics study in severe extracranial carotid artery stenosis.

ABSTRACT:

Background

Significant genetic association has been found in patients with severe carotid artery stenosis (CAS). The present study wished to investigate if metabolites may also act as biomarkers for CAS.

Methods

Consecutive patients with at least one carotid artery stenosis > = 60% on cerebral angiography were prospectively recruited from May 2007 to January 2016. Normal controls were recruited from outpatient clinic who had no stroke and coronary artery disease (CAD) history, and the brain magnetic resonance or computed tomographic angiography showed bilateral CAS < 30%. Risk factor profile, clinical characteristics, age, and clinical features were recorded. All subjects were male, and none had diabetes. ¹H-NMR spectroscopy-based metabolomics analysis was carried

SUBMITTER: Lee TH 

PROVIDER: S-EPMC6589885 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature