Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice.

ABSTRACT: Male fertility and sperm quality are negatively impacted by obesity. Furthermore, recent evidence has shown that male offspring from obese rat mothers also have reduced sperm quality and fertility. Here, we extend work in this area by comparing the effects of both maternal obesity and offspring post-weaning diet-induced obesity, as well as their combination, on sperm quality in mice. We additionally tested whether administration of the NAD+-booster nicotinamide mononucleotide (NMN) can ameliorate the negative effects of obesity and maternal obesity on sperm quality. We previously showed that intraperitoneal (i.p.) injection of NMN can reduce the metabolic deficits induced by maternal obesity or post-weaning dietary obesity in mice. In this study, female mice were fed a high-fat diet (HFD)

SUBMITTER: Youngson NA 

PROVIDER: S-EPMC6589912 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature