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Synthetic and Crystallographic Insight into Exploiting sp² Hybridization in the Development of α-l-Fucosidase Inhibitors.

ABSTRACT: The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α-l-fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel α-l-fucosidase inhibitors, with X-ray crystallographic analysis using an α-l-fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class.

SUBMITTER: Coyle T

PROVIDER: S-EPMC6589914 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Synthetic and Crystallographic Insight into Exploiting sp² Hybridization in the Development of α-l-Fucosidase Inhibitors.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Synthetic and Crystallographic Insight into Exploiting sp2 Hybridization in the Development of α-l-Fucosidase Inhibitors.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Synthetic and Crystallographic Insight into Exploiting sp² Hybridization in the Development of α-l-Fucosidase Inhibitors.