Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease.

ABSTRACT:

Background

Genetic variants currently known to affect coronary artery disease (CAD) risk explain less than one-quarter of disease heritability. The heritability contribution of gene regulatory networks (GRNs) in CAD, which are modulated by both genetic and environmental factors, is unknown.

Objectives

This study sought to determine the heritability contributions of single nucleotide polymorphisms affecting gene expression (eSNPs) in GRNs causally linked to CAD.

Methods

Seven vascular and metabolic tissues collected in 2 independent genetics-of-gene-expression studies of patients with CAD were used to identify eSNPs and to infer coexpression networks. To construct GRNs with causal relations to CAD, the prior information of eSNPs in the coexpression networks was used in

SUBMITTER: Zeng L 

PROVIDER: S-EPMC6590059 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature