Vimentin Intermediate Filament Rings Deform the Nucleus During the First Steps of Adhesion.

ABSTRACT: During cell spreading, cells undergo many changes to their architecture and their mechanical properties. Vimentin, as an integral part of the cell architecture, and its mechanical stability must adapt to the new state of the cell. This study focuses on the structures formed by vimentin during the first steps of cell adhesion. Very early, ball-like structures, or "knots," are seen and often vimentin filaments emerge in the shape of rings around the nucleus. Although intermediate filaments are not known to be associated to motor proteins to form contractile systems, these rings can nonetheless strongly deform the cell nucleus. In the first 6 to 12 h of adhesion, these vimentin knots and rings disappear, and the intermediate filament network returns to the state seen before detachment of the

SUBMITTER: Terriac E 

PROVIDER: S-EPMC6590062 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature